Inhibition of Perforant Path Input to the CA1 Region by Serotonin and Noradrenaline
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چکیده
منابع مشابه
Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline.
Bath-applied monoamines-dopamine (DA), serotonin (5-HT), and noradrenaline (NE)-strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input. The effect of DA action on PP field excitatory postsynaptic potential (fEPSP) has been characterized in detail, but relatively little is known about the NE and 5-HT effects. Here ...
متن کاملPerforant path inhibition by noradrenaline and serotonin JN-00217-2005.R1 Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline
Bath applied monoamines dopamine (DA), serotonin (5-HT), and noradrenaline (NE) strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input (Otmakhova and Lisman, 2000). The effect of DA action on PP field EPSP (fEPSP) has been characterized in detail (Otmakhova and Lisman, 1999), but relatively little is known about t...
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Subregional analyses of the hippocampus have suggested a selective role for the CA1 subregion in intermediate/long-term spatial memory and consolidation, but not short-term acquisition or encoding processes. It remains unclear how the direct cortical projection to CA1 via the perforant path (pp) contributes to these CA1-dependent processes. It has been suggested that dopamine selectively modula...
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Subregional analyses of the hippocampus suggest CA1-dependent memory processes rely heavily upon interactions between the CA1 subregion and entorhinal cortex. There is evidence that the direct perforant path (pp) projection to CA1 is selectively modulated by dopamine while having little to no effect on the Schaffer collateral (SC) projection to CA1. The current study takes advantage of this pha...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2005
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00217.2005